Leptin as a regulator of adipose mass and reproduction

被引：76

作者：

Chehab, FF ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2000年 / 21卷 / 08期

关键词：

D O I：

10.1016/S0165-6147(00)01514-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Leptin, an adipocyte-derived hormone, informs neuroendocrine pathways about the status of energy stores in adipose tissue. The integration of this peripheral signal in hypothalamic networks results in activation of peripheral metabolic pathways that control energy build-up and expenditure. Firing of the reproductive cascade of hormones at puberty and its regulation in adults is tightly associated with energy metabolism and is thus regulated by leptin. This article provides an update of past and present theories that link nutrition and reproduction in light of new research.

引用

页码：309 / 314

页数：6

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