Neuralized functions cell autonomously to regulate Drosophila sense organ development

被引:74
作者
Yeh, E
Zhou, L
Rudzik, N
Boulianne, GL
机构
[1] Hosp Sick Children, Res Inst, Program Dev Biol, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Zool, Toronto, ON, Canada
[3] Univ Toronto, Collaborat Program Dev Biol, Toronto, ON, Canada
[4] Univ Toronto, Dept Mol & Med Genet, Toronto, ON, Canada
关键词
Drosophila; neuralized; neurogenesis; sense organ;
D O I
10.1093/emboj/19.17.4827
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neurogenic genes, including Notch and Delta, are thought to play important roles in regulating cell-cell interactions required for Drosophila sense organ development. To define the requirement of the neurogenic gene neuralized (neu) in this process, two independent nea alleles were used to generate mutant clones. We find that nea is required for determination of cell fates within the proneural cluster and that cells mutant for neu autonomously adopt neural fates when adjacent to wild-type cells. Furthermore, nea is required within the sense organ lineage to determine the fates of daughter cells and accessory cells. To gain insight into the mechanism by which nea functions, we used the GAL4/UAS system to express wild-type and epitope-tagged neu constructs. We show that Neu protein is localized primarily at the plasma membrane. We propose that the function of neu in sense organ development is to affect the ability of cells to receive Notch-Delta signals and thus modulate neurogenic activity that allows for the specification of nonneuronal cell fates in the sense organ.
引用
收藏
页码:4827 / 4837
页数:11
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