Bimodal MR-PET Agent for Quantitative pH Imaging

被引：127

作者：

Frullano, Luca ^{[1
]}

Catana, Ciprian ^{[1
]}

Benner, Thomas ^{[1
]}

Sherry, A. Dean ^{[2
,3
]}

Caravan, Peter ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, AA Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[2] Univ Texas Dallas, Dept Chem, Dallas, TX 75230 USA

[3] Adv Imaging Res Ctr, Dallas, TX USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 13期

关键词：

gadolinium imaging agents magnetic resonance imaging; pH imaging positron emission tomography; POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO; CONTRAST AGENTS; BRAIN;

D O I：

10.1002/anie.201000075

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Two unknowns: The relaxivity of activatable magnetic resonance (MR) contrast agents depends on environmental factors, such as the pH value or enzymatic activity, but the MR signal depends on relaxivity and agent concentration. Simultaneous positron emission tomography (PET) and MR imaging (MRI) with the bimodal, pHresponsive M R-PET agent shown enabled the direct determination of concentration and T1, and hence the pH value. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2382 / 2384

页数：3

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