Intensity-based statistical scorer for tandem mass spectrometry

被引：107

作者：

Havilio, M ^{[1
]}

Haddad, Y ^{[1
]}

Smilansky, Z ^{[1
]}

机构：

[1] Compugen Ltd, IL-69512 Tel Aviv, Israel

来源：

ANALYTICAL CHEMISTRY | 2003年 / 75卷 / 03期

关键词：

D O I：

10.1021/ac0258913

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We describe a new statistical scorer for tandem mass spectrometry. The scorer is based on the probability that fragments with given chemical properties create measured intensity levels in the experimental spectrum. The scorer's parameters are computed using a fully automated procedure. Benchmarking the new scorer on a large set of experimental spectra, we show that it performs significantly better than the widely used cross-correlation scoring algorithm of Eng et al.

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页码：435 / 444

页数：10

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