Molecular printboards as a general platform for protein immobilization:: A supramolecular solution to nonspecific adsorption

被引：51

作者：

Ludden, Manon J. W.

Mulder, Alart

Tampe, Robert

Reinhoudt, David N.

Huskens, Jurriaan

机构：

[1] Univ Frankfurt, Biozentrum, Inst Biochem, D-60439 Frankfurt, Germany

[2] Univ Twente, Labs Mol Nanofabricat & Supramol Chem & Technol, MESA Inst Nanotechnol, NL-7500 AE Enschede, Netherlands

[3] Univ Twente, MESA Inst Nanotechnol, MESA Strateg Res Orientat Nanofabricat, NL-7500 AE Enschede, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 22期

关键词：

cyclodextrins; host-guest systems; noncovalent interactions; proteins; self-assembled monolayers;

D O I：

10.1002/anie.200605104

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Be specific: A supramolecular adsorbate consisting of an adamantyl group (red) and an oligo(ethylene glycol) chain has been desighed to prevent nonspecific protein adsorption at cyclodextrin molecular printboards. The adamantyl group allows specific and reversible interactions. Specific immobilization of proteins (gray) is possible through multivalent orthogonal linkers by effective replacement of the monovalent adsorbate (Ni2+ ions (green) may be needed; see picture). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4104 / 4107

页数：4

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