Guilt by association

被引：109

作者：

Altshuler, D ^{[1
]}

Daly, M

Kruglyak, L

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[3] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[5] MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA USA

[6] Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Seattle, WA 98104 USA

[7] Fred Hutchinson Canc Res Ctr, Div Human Biol, Genet Program, Seattle, WA 98104 USA

来源：

NATURE GENETICS | 2000年 / 26卷 / 02期

关键词：

D O I：

10.1038/79839

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Positional cloning of common disease genes is a central but elusive goal of human geneticists. Progress is now reported by Bell and colleagues in their study of NIDDM1, a locus implicated in type 2 diabetes. The complex nature of the reported association illustrates the challenge of implicating a specific gene and mutation in the causation of polygenic disease.

引用

页码：135 / 137

页数：3

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