Live now - pay by ageing: high performance mitochondrial activity in youth and its age-related side effects

被引：9

作者：

Hofhaus, G

Berneburg, M

Wulfert, M

Gattermann, N

机构：

[1] Univ Dusseldorf, Inst Biochem Geb 26 42 03, D-40225 Dusseldorf, Germany

[2] Univ Klinikum Dusseldorf, Hautklin, Dusseldorf, Germany

[3] Univ Klinikum Dusseldorf, Klin Hamatol Onkol & Klin Immunol, Dusseldorf, Germany

来源：

EXPERIMENTAL PHYSIOLOGY | 2003年 / 88卷 / 01期

关键词：

D O I：

10.1113/eph8802510

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Radical oxygen species are a byproduct of normal energy metabolism in mitochondria. The short-lived radicals cause damage to their immediate surrounding, i.e. the mitochondria. While most of this damage will be removed by normal mitochondrial turnover, damage to mitochondrial DNA (mtDNA) can persist and may accumulate with age. Recent evidence indicates that mutant mtDNA molecules can accumulate within individual cells, potentially hampering mitochondrial function.

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页码：167 / 174

页数：8

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