Fluctuations in closed-loop fluorescent particle tracking

被引：17

作者：

Berglund, Andrew J. ^{[1
]}

McHale, Kevin ^{[1
]}

Mabuchi, Hideo ^{[1
]}

机构：

[1] CALTECH, Pasadena, CA 91125 USA

来源：

OPTICS EXPRESS | 2007年 / 15卷 / 12期

关键词：

D O I：

10.1364/OE.15.007752

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a comprehensive theory of closed-loop particle tracking for calculating the statistics of a diffusing fluorescent particle's motion relative to the tracking lock point. A detailed comparison is made between the theory and experimental results, with excellent quantitative agreement found in all cases. A generalization of the theory of ( open-loop) fluorescence correlation spectroscopy is developed, and the relationship to previous results is discussed. Two applications of the statistical techniques are given: a method for determining a tracked particle's localization and an algorithm for rapid particle classification based on real-time analysis of the tracking control signal. (c) 2007 Optical Society of America.

引用

页码：7752 / 7773

页数：22

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