Sensing stretch is fundamental

被引：73

作者：

Epstein, ND ^{[1
]}

Davis, JS ^{[1
]}

机构：

[1] NHLBI, Mol Physiol Sect, Mol Cardiol Lab, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2003年 / 112卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(03)00037-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stretch induces changes in cardiomyocyte biology that are implicated in heart failure, but the mechanism by which stretch is sensed and signals are transduced is unknown. New understanding of the Z disc elements of contractile units are beginning to elucidate the mechanism of stretch sensing and its relation to cardiac adaptation and disease.

引用

页码：147 / 150

页数：4

共 21 条

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