A concise synthesis of the tricyclic skeleton of pleuromutilin and a new approach to cycloheptenes

被引：46

作者：

Bacqué, E

Pautrat, F

Zard, SZ ^{[1
]}

机构：

[1] Ecole Polytech, CNRS, Organ Synth Lab, F-91128 Palaiseau, France

[2] AVENTIS Pharma, F-93235 Romainville, France

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 03期

关键词：

D O I：

10.1021/ol027312m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short synthesis of the tricyclic skeleton of pleuromutilin is reported, featuring an unusually efficient 8-endo-trig radical cyclization of a xanthate precursor. In the course of this study, a one-carbon ring expansion leading to cycloheptenes was uncovered.

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页码：325 / 328

页数：4

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