Preparation of 4-substituted 10-ethylphenothiazines

被引：6

作者：

Ebdrup, S

Jensen, MS

Vedso, P

机构：

[1] Novo Nordisk AS, DK-2760 Malov, Denmark

[2] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 02期

关键词：

D O I：

10.1039/a704120i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under appropriate reaction conditions 10-ethylphenothiazine 1 undergoes lithiation at C-4 using an excess of sec-butyllithium-N,N,N',N'-tetramethyl in diethyl ether, Reaction of the lithiated intermediate with a variety of carbon, halogen, sulfur and silicon electrophiles affords several new 4-substituted 10-ethylphenothiazines 3a-i in good yields.

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收藏

页码：351 / 354

页数：4

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