Bacterial resistance to β-lactam antibiotics:: Compelling opportunism, compelling opportunity

被引：751

作者：

Fisher, JF ^{[1
]}

Meroueh, SO ^{[1
]}

Mobashery, S ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 02期

关键词：

D O I：

10.1021/cr030102i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bacteria thrive under extreme conditions and they can adjust easily so as to improve their fitness for survival. This review covers bacterial tolerance and resistance to the β-lactam antibiotics. It describes penicillin-binding proteins and β-lactamases. Under penicillin-binding proteins, enzymes of cell wall biosynthesis and β-lactam-sensing proteins are introduced. Under β-lactamases, the four classes of β-lactamases are described.

引用

页码：395 / 424

页数：30

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