The role of assembly in insulin's biosynthesis

被引：437

作者：

Dodson, G

Steiner, D

机构：

[1] Natl Inst Med Res, London NW7 1AA, England

[2] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England

[3] Univ Chicago, Howard Hughes Med Inst, Chicago, IL 60637 USA

[4] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0959-440X(98)80037-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin is synthesised as a single-chain precursor, preproinsulin, that contains an N-terminal signal sequence and a connecting peptide linking the A and B chains of the insulin molecule. Nascent proinsulin is directed into the regulated secretory pathway, converted to insulin and stored as microcrystals. These processes exploit assembly to the zinc-containing hexamer. Structural, chemical and genetic studies, and experiments with transgenic animals and transfected cells, are providing new details about the molecular events in insulin's biosynthesis.

引用

页码：189 / 194

页数：6

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