Absence of mutations in the key megakaryocyte transcriptional regulator FOG-1 in patients with idiopathic myelofibrosis

被引：5

作者：

Fisher, C ^{[1
]}

Steensma, D

Janmohamed, R

Kaczmarski, R

Reilly, JT

Vyas, P

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC Mol Haematol Unit, Oxford OX3 9DU, England

[2] Hillingdon Hosp, Dept Haematol, Uxbridge, Middx, England

[3] Royal Hallamshire Hosp, Dept Haematol, Sheffield S10 2JF, S Yorkshire, England

[4] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Dept Haematol, Oxford OX3 9DU, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 126卷 / 05期

关键词：

myleofibrosis; megakaryopoiesis; GATA1; FOG-1; transcription factors;

D O I：

10.1111/j.1365-2141.2004.05100.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：750 / 752

页数：3

共 8 条

[1] Different substitutions at residue D218 of the X-linked transcription factor GATA1 lead to altered clinical severity of macrothrombocytopenia and anemia and are associated with variable skewed X inactivation [J].

Freson, K ;

Matthijs, G ;

Thys, C ;

Mariën, P ;

Hoylaerts, MF ;

Vermylen, J ;

Van Geet, C .

HUMAN MOLECULAR GENETICS, 2002, 11 (02) :147-152

[2] Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome [J].

Gurbuxani, S ;

Vyas, P ;

Crispino, JD .

BLOOD, 2004, 103 (02) :399-406

[3] Lack of alteration in GATA-1 expression in CD34+ hematopoietic progenitors from patients with idiopathic myelofibrosis [J].

Martyré, MC ;

Steunou, V ;

Le Bousse-Kerdilès, MC ;

Wietzerbin, J .

BLOOD, 2003, 101 (12) :5087-5088

[4] Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1 [J].

Nichols, KE ;

Crispino, JD ;

Poncz, M ;

White, JG ;

Orkin, SH ;

Maris, JM ;

Weiss, MJ .

NATURE GENETICS, 2000, 24 (03) :266-270

[5] A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development [J].

Shivdasani, RA ;

Fujiwara, Y ;

McDevitt, MA ;

Orkin, SH .

EMBO JOURNAL, 1997, 16 (13) :3965-3973

[6] Development of myelofibrosis in mice genetically impaired for GATA-1low expression (GATA-1low mice) [J].

Vannucchi, AM ;

Bianchi, L ;

Cellai, C ;

Paoletti, F ;

Rana, RA ;

Lorenzini, R ;

Migliaccio, G ;

Migliaccio, AR .

BLOOD, 2002, 100 (04) :1123-1132

[7]

Vyas P, 1999, BLOOD, V93, P2867

[8] X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction [J].

Yu, CN ;

Niakan, KK ;

Matsushita, M ;

Stamatoyannopoulos, G ;

Orkin, SH ;

Raskind, WH .

BLOOD, 2002, 100 (06) :2040-2045

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