Numb, neurogenesis and epithelial polarity

被引：13

作者：

Kim, Seonhee ^{[1
]}

Walsh, Chris A. ^{[1
]}

机构：

[1] Childrens Hosp, Harvard Med Sch, Beth Israel Deaconess Med Ctr, Howard Hughes Med Inst Div Genet Program Neurosci, Boston, MA 02115 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 07期

关键词：

D O I：

10.1038/nn0707-812

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Numb's function in mammalian neural progenitors has been unclear. A paper in this issue shows a crucial role for Numb in the maintenance of radial glia adherens junctions and, consequently, the integrity of the neurogenic epithelium.

引用

页码：812 / 813

页数：3

共 15 条

[1] The endocytic protein α-adaptin is required for numb-mediated asymmetric cell division in Drosophila [J].

Berdnik, D ;

Török, T ;

González-Gaitán, M ;

Knoblich, JA .

DEVELOPMENTAL CELL, 2002, 3 (02) :221-231

[2] The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface [J].

Cappello, Silvia ;

Attardo, Alessio ;

Wu, Xunwei ;

Iwasato, Takuji ;

Itohara, Shigeyoshi ;

Wilsch-Braeuninger, Michaela ;

Eilken, Hanna M. ;

Rieger, Michael A. ;

Schroeder, Timm T. ;

Huttner, Wieland B. ;

Brakebusch, Cord ;

Goetz, Magdalena .

NATURE NEUROSCIENCE, 2006, 9 (09) :1099-1107

[3] Regulation of cerebral cortical size by control of cell cycle exit in neural precursors [J].

Chenn, A ;

Walsh, CA .

SCIENCE, 2002, 297 (5580) :365-369

[4] Postnatal deletion of numb/numblike reveals repair and remodeling capacity in the subventricular neurogenic niche [J].

Kuo, Chay T. ;

Mirzadeh, Zaman ;

Soriano-Navarro, Mario ;

Rasin, Mladen ;

Wang, Denan ;

Shen, Jie ;

Sestan, Nenad ;

Garcia-Verdugo, Jose ;

Alvarez-Buylla, Arturo ;

Jan, Lily Y. ;

Jan, Yuh-Nung .

CELL, 2006, 127 (06) :1253-1264

[5] Inactivation of numb and numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis [J].

Li, HS ;

Wang, DN ;

Shen, Q ;

Schonemann, MD ;

Gorski, JA ;

Jones, KR ;

Temple, S ;

Jan, LY ;

Jan, YN .

NEURON, 2003, 40 (06) :1105-1118

[6] αE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway [J].

Lien, WH ;

Klezovitch, O ;

Fernandez, TE ;

Delrow, J ;

Vasioukhin, V .

SCIENCE, 2006, 311 (5767) :1609-1612

[7] Neurons derived from radial glial cells establish radial units in neocortex [J].

Noctor, SC ;

Flint, AC ;

Weissman, TA ;

Dammerman, RS ;

Kriegstein, AR .

NATURE, 2001, 409 (6821) :714-720

[8] Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis [J].

Petersen, PH ;

Zou, KY ;

Krauss, S ;

Zhong, WM .

NATURE NEUROSCIENCE, 2004, 7 (08) :803-811

[9] Progenitor cell maintenance requires numb and numblike during mouse neurogenesis [J].

Petersen, PH ;

Zou, KY ;

Hwang, JK ;

Jan, YN ;

Zhong, WM .

NATURE, 2002, 419 (6910) :929-934

[10] Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors [J].

Rasin, Mladen-Roko ;

Gazula, Valeswara-Rao ;

Breunig, Joshua J. ;

Kwan, Kenneth Y. ;

Johnson, Matthew B. ;

Liu-Chen, Susan ;

Li, Hua-Shun ;

Jan, Lily Yeh ;

Jan, Yuh-Nung ;

Rakic, Pasko ;

Sestan, Nenad .

NATURE NEUROSCIENCE, 2007, 10 (07) :819-827

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