Synthetic studies on a marine polyether toxin, gambierol:: stereoselective synthesis of the FGH ring system via B-alkyl Suzuki coupling

被引：59

作者：

Fuwa, H

Sasaki, M ^{[1
]}

Tachibana, K

机构：

[1] Univ Tokyo, Dept Chem, Grad Sch Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Japan Sci & Technol Corp, CREST, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 43期

关键词：

coupling reactions; polyethers; Suzuki reactions; toxins;

D O I：

10.1016/S0040-4039(00)01483-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic route to the FGH ring system of gambierol, a marine polyether toxin isolated from the dinoflagellate Gambierdiscus toxicus, has been developed. The present synthesis features B-alkyl Suzuki coupling of the F and H rings, followed by ring-closure of the G ring and stereoselective installation of 1,3-diaxial methyl groups at C21 and C23. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8371 / 8375

页数：5

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