Inhibitors of pantothenate kinase: Novel antibiotics for staphylococcal infections

被引：74

作者：

Choudhry, AE

Mandichak, TL

Broskey, JP

Egolf, RW

Kinsland, C

Begley, TP

Seefeld, MA

Ku, TW

Brown, JR

Zalacain, M

Ratnam, K

机构：

[1] GlaxoSmithKline Pharmaceut, Microbial Musculoskeletal & Proliferat Dis & Bioi, Collegeville, PA 19426 USA

[2] Cornell Univ, Dept Chem & Biol Chem, Ithaca, NY 14850 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 06期

关键词：

D O I：

10.1128/AAC.47.6.2051-2055.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.

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页码：2051 / 2055

页数：5

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