Enhanced interleukin-1β and interleukin-18 release in a patient with chronic infantile neurologic, cutaneous, articular syndrome

被引：55

作者：

Janssen, R ^{[1
]}

Verhard, E ^{[1
]}

Lankester, A ^{[1
]}

ten Cate, R ^{[1
]}

van Dissel, JT ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, NL-2300 RC Leiden, Netherlands

来源：

ARTHRITIS AND RHEUMATISM | 2004年 / 50卷 / 10期

关键词：

D O I：

10.1002/art.20494

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome is a severe inflammatory disease that recently was associated with mutations in CIAS1. It was hypothesized that these mutations may lead to enhanced inflammatory responses. Herein, we provide evidence that inflammation in the CINCA syndrome is characterized by enhanced interleukin-1beta (IL-1beta) and IL-18 release upon stimulation of blood cells and show that this release is caspase I dependent.

引用

页码：3329 / 3333

页数：5

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