Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome inhibitors

被引：27

作者：

Overkleeft, HS ^{[1
]}

Bos, PR ^{[1
]}

Hekking, BG ^{[1
]}

Gordon, EJ ^{[1
]}

Ploegh, HL ^{[1
]}

Kessler, BM ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(00)00968-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid phase synthesis of the known proteasome inhibitor ZL(3)VS, using Kenner's safety catch protocol, is described. This methodology has been extended to the synthesis of various novel peptide vinyl sulfone and peptide epoxyketone derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6005 / 6009

页数：5

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