Demyelinating diseases and potential repair strategies

被引：28

作者：

Radtke, C.

Spies, M.

Sasaki, M.

Vogt, P. M.

Kocsis, J. D. ^{[1
]}

机构：

[1] VA Connecticut Healthcare Syst, Neurosci Res Ctr, West Haven, CT USA

[2] Yale Univ, Sch Med, Dept Neurol, West Haven, CT 06516 USA

[3] Med Hochsch Hannover, Dept Plast & Hand & Reconstruct Surg, Hannover, Germany

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2007年 / 25卷 / 03期

关键词：

demyelination; remyelination; peripheral myelin forming cells; transplantation;

D O I：

10.1016/j.ijdevneu.2007.02.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Demyelination is associated with a number of neurological disorders including multiple sclerosis (MS), spinal cord injury and nerve compression. MS lesions often show axon loss and therefore reparative therapeutic goals include remyelination and neuroprotection of vulnerable axons. Experimental cellular transplantation has proven successful in a number of demyelination and injury models to remyelinate and improve functional outcome. Here we discuss the remyelination and neuroprotective potential of several myelin-forming cells types and their behavior in different demyelination and injury models. Better understanding of these models and current cell-based strategies for remyelination and neuroprotection offer exciting opportunities to develop strategies for clinical studies. (C) 2007 ISDN. Published by Elsevier Ltd. All rights reserved.

引用

页码：149 / 153

页数：5

共 60 条

[1] Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord [J].