5-HT in the dorsal raphe nucleus is involved in the effects of 100-Hz electro-acupuncture on the pain-depression dyad in rats

被引：47

作者：

Wu, Yuan-Yuan ^{[1
]}

Jiang, Yong-Liang ^{[1
]}

He, Xiao-Fen ^{[1
]}

Zhao, Xiao-Yun ^{[2
]}

Shao, Xiao-Mei ^{[1
]}

Sun, Jing ^{[1
]}

Shen, Zui ^{[1
]}

Shou, Shen-Yun ^{[1
]}

Wei, Jun-Jun ^{[1
]}

Ye, Jia-Yu ^{[1
]}

Yan, Si-Si ^{[1
]}

Fang, Jian-Qiao ^{[1
]}

机构：

[1] Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China

[2] Shanxi Hosp Tradit Chinese Med, Dept Orthoped & Traumatol, Xian 710000, Shanxi, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2017年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

pain-depression dyad; electro-acupuncture; 5-hydroxytryptamine; dorsal raphe nucleus; rat; FREQUENCY ELECTROACUPUNCTURE; ACUPUNCTURE STIMULATION; STRESS; MODEL; MECHANISMS; MODULATION; BEHAVIOR; ANXIETY; EMOTION; SYSTEM;

D O I：

10.3892/etm.2017.4479

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The pain-depression dyad is becoming widespread in the clinic and is attracting increasing attention. A previous study by our group found that 100-Hz electro-acupuncture (EA), but not 2-, 50- and 2/100-Hz EA, was effective against the reserpine-induced pain-depression dyad. This finding is in contrast to the fact that low-frequency EA is commonly used to treat supraspinal-originating diseases. The present study aimed to investigate the mechanism underlying the effects of 100-Hz EA on the pain-depression dyad. Repeated reserpine injection was found to induce allodynia and depressive behaviors in rats. It decreased 5-hydroxytryptamine (5-HT) levels and immunoreactive expressions in the dorsal raphe nucleus (DRN). 100-Hz EA alleviated the pain-depression dyad and upregulated 5-HT in the DRN of reserpine-injected rats. Intracerebroventricular injection of para-chlorophenylalanine, an inhibitor of 5-HT resynthesis, suppressed the upregulation of 5-HT in the DRN by 100-Hz EA and partially counteracted the analgesic and anti-depressive effects of 100-Hz EA. The present study was the first to demonstrate that 5-HT in the DRN is involved in mediating the analgesic and anti-depressive effects of 100-Hz EA on the pain-depression dyad. This finding provided a scientific basis for high-frequency EA as a potential treatment for the pain-depression dyad.

引用

页码：107 / 114

页数：8

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