Isoxazolinoisoquinoline heterocycles via solid-phase Reissert and Suzuki reactions

被引：61

作者：

Lorsbach, BA ^{[1
]}

Bagdanoff, JT ^{[1
]}

Miller, RB ^{[1
]}

Kurth, MJ ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 07期

关键词：

D O I：

10.1021/jo9720142

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A traceless solid-phase synthesis strategy has been developed that delivers novel isoxazolinoisoquinoline heterocycles. The process consists of solid-phase Reissert formation (isoquinoline --> I), Suzuki coupling lithiation, and subsequent C1-alkylation (I --> II), and exo-olefin selective 1,3-dipolar nitrile oxide cycloaddition followed by Reissert; hydrolysis (II --> III) to liberate the targeted heterocycle.

引用

页码：2244 / 2250

页数：7

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