Developmental expression of the ngf receptor p140trk in the septohippocampal system of the rat:: A quantitative analysis

被引：10

作者：

Cirulli, F ^{[1
]}

Shooter, EM

Levine, S

机构：

[1] Ist Super Sanita, Behav Pathophysiol Sect, Lab Fisiopatol Organo & Sistema, I-00161 Rome, Italy

[2] Stanford Univ, Neurosci Program, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA

[4] Univ Delaware, Dept Psychol, Newark, DE 19716 USA

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 1997年 / 15卷 / 07期

关键词：

nerve growth factor; p140(trk); septohippocampal system; gene expression; development; rat;

D O I：

10.1016/S0736-5748(97)00020-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An RNAse protection assay was used to identify p140(trk) mRNA in the developing rat septohippocampal system. In both the septum and hippocampus, levels of p140(trk) mRNA were low at birth and increased thereafter. Levels of transcripts were found to be much higher in the septum than in the hippocampus, whereas another brain region, the hypothalamus, showed levels of expression intermediate between these two structures. Only one isoform of the p140(trk) receptor was found to be expressed in the rat central nervous system (CNS) during development. This isoform corresponds to the one preferentially expressed in neural tissues in the adult animal. These data show that expression of the high affinity nerve growth factor (NGF) receptor is developmentally regulated during postnatal brain development and suggest that it might mediate NGF effects on developing central cholinergic systems. (C) 1997 ISDN. Published by Elsevier Science Ltd.

引用

页码：901 / 909

页数：9

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