Fabrication of planar nanofluidic channels in a thermoplastic by hot-embossing and thermal bonding

被引:99
作者
Abgrall, Patrick
Low, Lee-Ngo
Nguyen, Nam-Trung
机构
[1] Nanyang Technol Univ, Singapore MIT Alliance, Singapore, Singapore
[2] Singapore Polytech, Singapore, Singapore
关键词
D O I
10.1039/b616134k
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Planar nanochannels are of particular significance in nanofluidics: keeping the width on the micrometre scale prevents the use of nanolithography while the depth stays in the nanometric range, i.e. below 100 nm. Fabrication of wide and shallow nanochannels in a plastic is known to be challenging due to the collapse of the structure during the sealing step. In this Technical Note, we demonstrate the simple and low-cost fabrication without nanolithography of monolithic and planar nanochannels by hot-embossing and bonding below the glass transition temperature.
引用
收藏
页码:520 / 522
页数:3
相关论文
共 25 条
[1]   Fabrication and characterization of poly(methylmethacrylate) microfluidic devices bonded using surface modifications and solvents [J].
Brown, L ;
Koerner, T ;
Horton, JH ;
Oleschuk, RD .
LAB ON A CHIP, 2006, 6 (01) :66-73
[2]   1-D nanochannels fabricated in polyimide [J].
Eijkel, JCT ;
Bomer, J ;
Tas, NR ;
van den Berg, A .
LAB ON A CHIP, 2004, 4 (03) :161-163
[3]   DNA fragment sizing by single molecule detection in submicrometer-sized closed fluidic channels [J].
Foquet, M ;
Korlach, J ;
Zipfel, W ;
Webb, WW ;
Craighead, HG .
ANALYTICAL CHEMISTRY, 2002, 74 (06) :1415-1422
[4]   Nanofilter array chip for fast gel-free biomolecule separation [J].
Fu, JP ;
Mao, P ;
Han, JY .
APPLIED PHYSICS LETTERS, 2005, 87 (26) :1-3
[5]   Entropic trapping and sieving of long DNA molecules in a nanofluidic channel [J].
Han, J ;
Craighead, HG .
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS, 1999, 17 (04) :2142-2147
[6]   Wet anisotropic etching for fluidic 1D nanochannels [J].
Haneveld, J ;
Jansen, H ;
Berenschot, E ;
Tas, N ;
Elwenspoek, M .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2003, 13 (04) :S62-S66
[7]   CO2-laser micromachining and back-end processing for rapid production of PMMA-based microfluidic systems [J].
Klank, H ;
Kutter, JP ;
Geschke, O .
LAB ON A CHIP, 2002, 2 (04) :242-246
[8]   Fabrication of plastic microchips by hot embossing [J].
Kricka, LJ ;
Fortina, P ;
Panaro, NJ ;
Wilding, P ;
Alonso-Amigo, G ;
Becker, H .
LAB ON A CHIP, 2002, 2 (01) :1-4
[9]   A packaging technique for polymer microfluidic platforms [J].
Lai, SY ;
Cao, X ;
Lee, LJ .
ANALYTICAL CHEMISTRY, 2004, 76 (04) :1175-1183
[10]   Fabrication of PMMA micro- and nanofluidic channels by proton beam writing: electrokinetic and morphological characterization [J].
Mahabadi, Kambiz Ansari ;
Rodriguez, Isabel ;
Haur, Sow Chorng ;
van Kan, Jeroen Anton ;
Bettiol, Andrew Anthony ;
Watt, Frank .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2006, 16 (07) :1170-1180