Smoking and colorectal adenomas: a case-control study

被引:38
作者
Almendingen, K
Hofstad, B
Trygg, K
Hoff, G
Hussain, A
Vatn, MH
机构
[1] Univ Oslo, Natl Hosp, Dept Med A, N-0027 Oslo, Norway
[2] Ulleval Univ Hosp, Dept Med, Oslo, Norway
[3] Univ Oslo, Inst Nutr Res, Oslo, Norway
[4] Telemark Cent Hosp, Dept Med, Skien, Norway
[5] Univ Oslo, Natl Hosp, Ctr Clin Epidemiol, N-0316 Oslo, Norway
关键词
adenoma cases; case-control study; colorectal adenoma; colorectal cancer; control group; diet; risk factor; smoking; tobacco;
D O I
10.1097/00008469-200006000-00008
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A positive association between tobacco and colorectal adenomas has been suggested. Smoking is, however, also associated with 'poor' dietary habits, which in turn may be related to risk of adenomas. It is therefore of interest to study the relationship between smoking, diet and risk of colorectal adenomas in follow-up studies. We compared 87 adenoma cases to 35 'hospital' and 35 healthy controls (all controls were age- and ses-matched and proven to be free of adenomas), Smoking data were collected by an interview and a self-administrated questionnaire with a time interval of at least one month. After 3 years of follow-up, all polyps were removed. Our data indicate that smoking is associated with adenoma prevalence, but not necessarily with size, multiplicity, growth or recurrence of adenomas. Compared to both sets of controls, cases reported to have smoked more than 15 pack-years, or who are current smokers, had a fourfold increased frequency of adenomas (odds ratios 3.6-5.9). Smokers with adenomas had dietary habits that may also be associated with adenomas. The smoking estimates remained largely unchanged even after adjustments for dietary variables in multivariate analysis. This study lends support to the theory of an initiating role of tobacco smoke in neoplasia formation. (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码:193 / 203
页数:11
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