B Cells Promote Pancreatic Tumorigenesis

被引：49

作者：

Roghanian, Ali ^{[1
,2
,3
]}

Fraser, Christopher ^{[1
,2
]}

Kleyman, Marianna ^{[1
,2
]}

Chen, Jianzhu ^{[1
,2
]}

机构：

[1] MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA USA

[3] Univ Southampton, Southampton Gen Hosp, Canc Sci Unit, Fac Med,Antibody & Vaccine Grp, Southampton, Hants, England

来源：

CANCER DISCOVERY | 2016年 / 6卷 / 03期

关键词：

CHEMOTHERAPY;

D O I：

10.1158/2159-8290.CD-16-0100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Three recent studies, approaching the question from different angles and using different and/or overlapping models, provide compelling evidence for the involvement of tumor-infiltrating B cells in the initiation and progression of pancreatic ductal adenocarcinoma. These studies highlight the need for a better understanding of pancreatic tumor-immune system interactions and the immunologic mechanisms that promote or inhibit tumorigenesis, paving the way for better treatment strategies. (C) 2016 AACR.

引用

收藏

页码：230 / 232

页数：3

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