Patterning of frontal cortex subdivisions by Fgf17

被引：121

作者：

Cholfin, Jeremy A.

Rubenstein, John L. R.

机构：

[1] Univ Calif San Francisco, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Med Scientist Training Program, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Grad Program Neurosci, San Francisco, CA 94143 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 18期

关键词：

arealization; regionalization; forebrain; protomap; neocortex;

D O I：

10.1073/pnas.0702225104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.

引用

页码：7652 / 7657

页数：6

共 41 条

[1] Meeting of minds: the medial frontal cortex and social cognition [J].