The biology of melanocytes

被引：93

作者：

Sulaimon, SS ^{[1
]}

Kitchell, BE ^{[1
]}

机构：

[1] Univ Illinois, Vet Med Teaching Hosp, Dept Vet Clin Med, Urbana, IL 61802 USA

来源：

VETERINARY DERMATOLOGY | 2003年 / 14卷 / 02期

关键词：

keratinocytes; melanin; melanocytes; melanocytes-stimulating hormone; melanosomes; tyrosinase; ultraviolet radiation;

D O I：

10.1046/j.1365-3164.2003.00327.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In veterinary medicine, our understanding of the biology and regulation of melanocytic function is mostly based on information realized from human and murine studies. Improved understanding of the biology of melanocytes is needed to develop more effective treatment regimens for malignant melanoma and other melanocytic disorders. In vertebrates, melanocytes are well known for their role in skin pigmentation, hair and feather coloration, and for their ability to produce and distribute melanin to surrounding keratinocytes. Enzymes involved in melanin synthesis are present exclusively in melanosomes. The type of melanin synthesized by melanocytes in mammals is regulated at a genetic, biochemical and environmental level. These regulatory factors affect not only the phenotypic appearance, but also the photoprotective properties of melanin. This review addresses the biology of melanocytes, melanin synthesis and the photoprotective properties of melanin.

引用

页码：57 / 65

页数：9

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