Characterization of Arabidopsis decapping proteins AtDCPI and AtDCP2, which are essential for post-embryonic development

被引：64

作者：

Iwasaki, Shintaro ^{[1
]}

Takeda, Atsushi ^{[1
]}

Motose, Hiroyasu ^{[1
]}

Watanabe, Yuichiro ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci, Meguro Ku, Tokyo 1538902, Japan

来源：

FEBS LETTERS | 2007年 / 581卷 / 13期

关键词：

mRNA turnover; decapping; DCP1; DCP2; processing body; arabidopsis thaliana;

D O I：

10.1016/j.febslet.2007.04.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although decapping is an important process in eukaryotic mRNA turnover, little is known about this process in plants. Here, we identified Arabidopsis thaliana decapping proteins AtDCP1 and AtDCP2 and showed that (I) AtDCP2 is an active decapping enzyme, (II) AtDCP1 interacts with itself, (III) AtDCP1 and AtDCP2 are localized to cytoplasmic foci (putative Arabidopsis processing body), and (IV) AtDCP1 and AtDCP2 are essential for post-embryonic development. Our findings provide new insights into the role of decapping-dependent mRNA turnover. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2455 / 2459

页数：5

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