Nanoencapsulation of stem cells within polyelectrolyte multilayer shells

被引：149

作者：

Veerabadran, Nalinkanth G.

Goli, Poorna L.

Stewart-Clark, Skylar S.

Lvov, Yuri M.

Mills, David K.

机构：

[1] Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71272 USA

[2] Louisiana Tech Univ, Sch Biol Sci, Ruston, LA 71272 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2007年 / 7卷 / 07期

关键词：

encapsulation; layer-by-layer; mesenchymal stem cells; nanolayers; polyelectrolytes; ENCAPSULATION; DELIVERY; GROWTH; ACID; RELEASE;

D O I：

10.1002/mabi.200700061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mouse mesenchymal stem cells have been individually encased by polyelectrolyte layers of poly (L-lysine) and hyaluronic acid using the electrostatic layer-by-layer assembly technique, resulting in a shell consisting of nanolayers of thickness around 6-9 nm. Maintenance of cell morphology and viability were demonstrated for up to one week. Further adjustments to shell permeability and flexibility will facilitate the use of these encapsulated cells in tissue engineering and targeted-delivery applications. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：877 / 882

页数：6

共 27 条

[1] Electrostatic layer-by-layer nanoassembly on biological microtemplates: Platelets [J].