Oral anticoagulants in the elderly

被引：35

作者：

Froom, P ^{[1
]}

Miron, E

Barak, M

机构：

[1] Clalit Hlth Serv, Cent Lab Haifa & Western Galilee, Haematol Labs, Nesher, Israel

[2] Clalit Hlth Serv, Informat Management Unit, Nesher, Israel

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 120卷 / 03期

关键词：

INR; elderly; anticoagulation; control; instability;

D O I：

10.1046/j.1365-2141.2003.04110.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over a 1-year period, 34 998 prothrombin time tests were performed on 2379 patients aged 40-89 years with a recommended target International Normalized Ratio (INR) value of 2.5. At least one INR value of greater than or equal to 5 was found in 507/2379 patients (21.3%). The elderly demonstrated higher maximum and lower minimum INR values, lower warfarin doses, and an increased number of tests performed. After adjustment for these factors, the risk of INR values greater than or equal to 5 increased with age by 15% every 10 years (95% CI 4-28%). We conclude that age is a risk factor for more unstable prothrombin time results.

引用

页码：526 / 528

页数：3

共 11 条

[1] Oral anticoagulation and hemorrhagic complications in an elderly population with atrial fibrillation [J].

Copland, M ;

Walker, ID ;

Tait, RC .

ARCHIVES OF INTERNAL MEDICINE, 2001, 161 (17) :2125-2128

[2] Reliability of delayed prothrombin time INR determinations in a central laboratory using off-site blood sampling [J].

Froom, P ;

Abramova, D ;

Bar-El, M ;

Barak, M .

CLINICAL AND LABORATORY HAEMATOLOGY, 2001, 23 (03) :189-192

[3] EFFECT OF AGE UPON THE INDUCTION AND MAINTENANCE OF ANTICOAGULATION WITH WARFARIN [J].

GLADMAN, JRF ;

DOLAN, G .

POSTGRADUATE MEDICAL JOURNAL, 1995, 71 (833) :153-155

[4] Mechanism of action, clinical effectiveness, and optimal therapeutic range [J].

Hirsh, J ;

Dalen, JE ;

Anderson, DR ;

Poller, L ;

Bussey, H ;

Ansell, J ;

Deykin, D ;

Brandt, JT .

CHEST, 1998, 114 (05) :445S-469S

[5] Safety of treatment with oral anticoagulants in the elderly - A systematic review [J].

Hutten, BA ;

Lensing, AWA ;

Kraaijenhagen, RA ;

Prins, MH .

DRUGS & AGING, 1999, 14 (04) :303-312

[6] Prospective study of the outcomes of ambulatory patients with excessive warfarin anticoagulation [J].

Hylck, EM ;

Chang, YC ;

Skates, SJ ;

Hughes, RA ;

Singer, DE .

ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (11) :1612-1617

[7] Analysis of risk factors for over-anticoagulation in patients receiving long-term warfarin [J].

Panneerselvam, S ;

Baglin, C ;

Lefort, W ;

Baglin, T .

BRITISH JOURNAL OF HAEMATOLOGY, 1998, 103 (02) :422-424

[8] Age-dependent differences in the anticoagulant effect of phenprocoumon in patients after heart valve surgery [J].

Russmann, S ;

GohlkeBarwolf, C ;

Jahnchen, E ;

Trenk, D ;

Roskamm, H .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1997, 52 (01) :31-35

[9] Quality of anticoagulation management among patients with atrial fibrillation -: Results of a review of medical records from 2 communities [J].

Samsa, GP ;

Matchar, DB ;

Goldstein, LB ;

Bonito, AJ ;

Lux, LJ ;

Witter, DM ;

Bian, J .

ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (07) :967-973

[10]

vanderMeer FJM, 1996, THROMB HAEMOSTASIS, V76, P12

← 1 2 →