Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells

被引：300

作者：

Shyu, WC

Lin, SZ

Yang, HI

Tzeng, YS

Pang, CY

Yen, PS

Li, H ^{[1
]}

机构：

[1] Acad Sinica, Inst Mol Biol, Taipei, Taiwan

[2] Tzu Chi Univ, Tzu Chi Buddhist Gen Hosp, Neuromed Sci Ctr, Dept Neurol, Hualien, Taiwan

[3] Natl Yang Ming Univ, Inst Biochem, Taipei 112, Taiwan

来源：

CIRCULATION | 2004年 / 110卷 / 13期

关键词：

granulocyte colony-stimulating factor; neuronal plasticity; stem cells; hematopoietic; stroke;

D O I：

10.1161/01.CIR.0000142616.07367.66

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists. Methods and Results-Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia. Conclusions-G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.

引用

页码：1847 / 1854

页数：8

共 28 条

[1]

BODINE DM, 1994, BLOOD, V84, P1482

[2] Early assessment of motor dysfunctions aids in successful occlusion of the middle cerebral artery [J].