Dominant nonresponsiveness to Helicobacter pylori infection is associated with production of interleukin 10 but not gamma interferon

被引：60

作者：

Sutton, P ^{[1
]}

Kolesnikow, T ^{[1
]}

Danon, S ^{[1
]}

Wilson, J ^{[1
]}

Lee, A ^{[1
]}

机构：

[1] Univ New S Wales, Sch Microbiol & Immunol, Sydney, NSW 2052, Australia

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 08期

关键词：

D O I：

10.1128/IAI.68.8.4802-4804.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Helicobacter pylori-induced gastritis is an essential precursor lesion for the development of peptic ulcers or gastric adenocarcinoma. We demonstrate that nonresponsiveness to H. pylori SS1 infection is dominantly inherited in mice. F-1 hybrid crosses between a nonresponder mouse and three responder strains all possessed the nonresponder phenotype. Secretion of interleukin-10 but not gamma interferon was associated with nonresponsiveness to infection.

引用

页码：4802 / 4804

页数：3

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