Olfactory Bulbectomy Induced Oxidative and Cell Damage in Rat: Protective Effect of Melatonin

被引：34

作者：

Tasset, I. ^{[1
]}

Medina, F. J. ^{[1
]}

Pena, J. ^{[2
]}

Jimena, I. ^{[2
]}

Del Carmen Munoz, M. ^{[1
]}

Salcedo, M. ^{[1
]}

Ruiz, C. ^{[1
]}

Feijoo, M. ^{[1
]}

Montilla, P. ^{[1
,3
]}

Tunez, I. ^{[1
]}

机构：

[1] Univ Cordoba, Dept Bioquim & Biol Mol, Fac Med, IMIBIC, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain

[2] Univ Cordoba, Fac Med, Dept Morphol Sci, E-14004 Cordoba, Spain

[3] Reina Sofia Univ Hosp, Dept Clin Anal, Cordoba, Spain

来源：

PHYSIOLOGICAL RESEARCH | 2010年 / 59卷 / 01期

关键词：

Antioxidant; Depression; Melatonin; Olfactory bulbectomy; Oxidative stress; FORCED SWIM TEST; MAJOR DEPRESSION; REACTIVE OXYGEN; NEURONAL DEATH; STRESS; MODEL; DERIVATIVES; FLUOXETINE; DISORDER; SURVIVAL;

D O I：

10.33549/physiolres.931684

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

In this study we analyzed the effects of melatonin (Mel, 1 mg/kg ip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.

引用

页码：105 / 112

页数：8

共 43 条

[1]

Searching for behavioral indicators of bipolar II in patients presenting with major depressive episodes: the "red sign," the "rule of three'' and other biographic signs of temperamental extravagance, activation and hypomania [J].