Bcr-Abl and inhibition of apoptosis in chronic myelogenous leukemia cells

被引：35

作者：

Fernandez-Luna, JL ^{[1
]}

机构：

[1] Hosp Univ Marques de Valdecilla, Immunol Unit, Mol Biol Lab, Santander 39008, Spain

来源：

APOPTOSIS | 2000年 / 5卷 / 04期

关键词：

apoptosis; Bcl-x(L); Bcr-Abl; signaling; transcription factor;

D O I：

10.1023/A:1009623222534

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic myelogenous leukemia (CML) cells are highly resistant to apoptosis induced by chemotherapeutic drugs. The observation that production of Bcr-Abl is the initiating event in CML has focussed attention on the survival signals triggered by this oncogene. A number of signal transducers and transcription factors have been associated with the antiapoptotic phenotype of CML cells, some of which lead to the expression and/or activation of members of the Bcl-2 family of apoptosis modulators, such as Bcl-x(L) and Bad. In this article, recent advances in understanding the antiapoptotic pathways triggered by Bcr-Abl in CML cells, are discussed.

引用

页码：315 / 318

页数：4

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