Intrinsic and extrinsic modulation of a single central pattern generating circuit

被引:70
作者
Morgan, PT
Perrins, R
Lloyd, PE
Weiss, KR
机构
[1] Mt Sinai Sch Med, Dept Physiol & Biophys, New York, NY 10029 USA
[2] Univ Bristol, Dept Biol Sci, Bristol BS8 1U9, Avon, England
[3] Univ Chicago, Dept Pharmacol Sci, Chicago, IL 60637 USA
[4] Univ Chicago, Comm Neurobiol, Chicago, IL 60637 USA
关键词
D O I
10.1152/jn.2000.84.3.1186
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Intrinsic and extrinsic neuromodulation are both thought to be responsible for the flexibility of the neural circuits (central pattern generators) that control rhythmic behaviors. Because the two forms of modulation have been studied in different circuits, it has been difficult to compare them directly. We find that the central pattern generator for biting in Aplysia is modulated both extrinsically and intrinsically. Both forms of modulation increase the frequency of motor programs and shorten the duration of the protraction phase. Extrinsic modulation is mediated by the serotonergic metacerebral cell (MCC) neurons and is mimicked by application of serotonin. Intrinsic modulation is mediated by the cerebral peptide-2 (CP-2) containing CBI-2 interneurons and is mimicked by application of CP-2. Since the effects of CBI-2 and CP-2 occlude each other, the modulatory actions of CBI-2 may be mediated by CP-2 release. Although the effects of intrinsic and extrinsic modulation are similar, the neurons that mediate them are active predominantly at different times, suggesting a specialized role for each system. Metacerebral cell (MCC) activity predominates in the preparatory (appetitive) phase and thus precedes the activation of CBI-2 and biting motor programs. Once the CBI-2s are activated and the biting motor program is initiated, MCC activity declines precipitously. Hence extrinsic modulation prefacilitates biting, whereas intrinsic modulation occurs during biting. Since biting inhibits appetitive behavior, intrinsic modulation cannot be used to prefacilitate biting in the appetitive phase. Thus the sequential use of extrinsic and intrinsic modulation may provide a means for premodulation of biting without the concomitant disruption of appetitive behaviors.
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页码:1186 / 1193
页数:8
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