The cDNA cloning and ontogeny of mouse α-synuclein

被引：38

作者：

Hong, L

Ko, HW

Gwag, BJ

Joe, E

Lee, S

Kim, YT

Suh, YH ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Pharmacol, Seoul 110799, South Korea

[2] Ajou Univ, Sch Med, Inst Med Sci, Dept Mol Biol Lab, Suwon 441749, South Korea

[3] Ajou Univ, Sch Med, Inst Med Sci, Dept Immunol Lab, Suwon 441749, South Korea

[4] Ajou Univ, Sch Med, Dept Pharmacol, Suwon 441749, South Korea

来源：

NEUROREPORT | 1998年 / 9卷 / 06期

关键词：

Alzheimer's disease; in situ hybridization; mouse alpha-synuclein cDNA; Parkinson's disease;

D O I：

10.1097/00001756-199804200-00051

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ALPHA-SYNUCLEIN has been implicated in the pathogenesis of Parkinson's disease. To investigate the role of alpha-synuclein in the brain, the cDNA clone encoding the mouse cognate of the human alpha-synuclein was isolated from a mouse brain cDNA library. The open reading frame coded for 140 amino acids that share 95% identity with human alpha-synuclein. Northern blot analysis showed that alpha-synuclein mRNA was primarily expressed in brain and spleen of adult mouse. In situ hybridization histochemistry revealed the highest expression of alpha-synuclein mRNA in the hippocampal formation and neocortex of the adult mouse. alpha-Synuclein mRNA expression in the brain was first observed in the hippocampus and neocortex on postnatal day 1. Levels of alpha-synuclein mRNA in these forebrain areas were nearly maximal at postnatal day 7 and remained relatively high until the adult stage. alpha-Synuclein mRNA was expressed in the liver transiently during embryogenesis. (C) 1998 Rapid Science Ltd.

引用

页码：1239 / 1243

页数：5

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