Homocysteine inhibits the proliferation and invasive potential of HT-1080 human fibrosarcoma cells

被引：12

作者：

Chavarría, T ^{[1
]}

Sánchez-Jiménez, F ^{[1
]}

Quesada, AR ^{[1
]}

Medina, MA ^{[1
]}

机构：

[1] Univ Malaga, Fac Sci, Dept Mol Biol & Biochem, E-29071 Malaga, Spain

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 301卷 / 02期

关键词：

homocysteine; proliferation; invasion; fibrosarcoma; zymography; urokinase;

D O I：

10.1016/S0006-291X(02)03081-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The impairment of homocysteine metabolism has been related to several disorders and diseases. Recently, homocysteine has been shown to inhibit key steps of angiogenesis, including endothelial cell proliferation, invasion, and remodeling of the extracellular matrix. Since these are also key steps in tumor invasion and metastasis, it can be hypothesized that homocysteine can also interfere in these processes. Therefore, we studied the effects of homocysteine on tumor proliferation and invasion, as well as on urokinase, a key extracellular matrix-degrading protease, using a model human tumor cell line. This study demonstrates that, in fact, homocysteine inhibits HT-1080 proliferation and invasion, and is a potent inhibitor of tumor cell urokinase expression. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：540 / 544

页数：5

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