Retrospective analysis of the use of cyclosporine in myasthenia gravis

被引：69

作者：

Ciafaloni, E ^{[1
]}

Nikhar, NK ^{[1
]}

Massey, JM ^{[1
]}

Sanders, DB ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Div Neurol, Durham, NC 27710 USA

来源：

NEUROLOGY | 2000年 / 55卷 / 03期

关键词：

D O I：

10.1212/WNL.55.3.448

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors reviewed the records of patients with myasthenia gravis who took cyclosporine for at least 6 months between November 1987 and January 1999. Of 57 patients who took cyclosporine for an average of 3.5 years, 55 (96%) had clinical improvement. The median time to best clinical response was 7 months. Corticosteroids were discontinued or decreased in 95% of 38 patients taking them. Major side effects included elevated serum creatinine (28%) and malignancy (11%). Five percent could not afford or tolerate the drug.

引用

页码：448 / 450

页数：3

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