PEG-dichlorotriazine (PEG-DCT): A new soluble polymer-supported scavenger for alcohols, thiols, phosphines, and phosphine oxides

被引：37

作者：

Falchi, A ^{[1
]}

Taddei, M ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 22期

关键词：

D O I：

10.1021/ol0002222

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Trichlorotriazine was reacted with MeO-PEG-OH (M-w 5000) to give a PEG dichlorotriazine (PEG-DCT) that was used as a soluble electrophilic scavenger. PEG-DCT was added at the end of reactions to completely remove nucleophilic reactants or byproducts, The soluble polymer sequestered alcohols, thiols, triphenylphosphine, and triphenylphosphine oxide.

引用

页码：3429 / 3431

页数：3

共 25 条

[1] A poly(ethylene glycol)-supported quaternary ammonium salt: An efficient, recoverable, and recyclable phase-transfer catalyst [J].

Annunziata, R ;

Benaglia, M ;

Cinquini, M ;

Cozzi, F ;

Tocco, G .

ORGANIC LETTERS, 2000, 2 (12) :1737-1739

[2]

APPLE R, 1976, ANGEW CHEM INT EDIT, V14, P801

[3] Arylsulfonate esters in solid phase organic synthesis. II. Compatibility with commonly-used reaction conditions [J].

Baxter, EW ;

Rueter, JK ;

Nortey, SO ;

Reitz, AB .

TETRAHEDRON LETTERS, 1998, 39 (09) :979-982

[4] A liquid-phase process suitable for large-scale synthesis of phosphorothioate oligonucleotides [J].

Bonora, GM ;

Rossin, R ;

Zaramella, S ;

Cole, DL ;

Eleuteri, A ;

Ravikumar, VT .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2000, 4 (03) :225-231

[5]

BONORA GM, 1998, CHIM IND-MILAN, V80, P887

[6] Solid-supported reagent strategies for rapid purification of combinatorial synthesis products [J].

Booth, RJ ;

Hodges, JC .

ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (01) :18-26

[7]

DRERY DH, 1999, MED CHEM RES, V9, P97

[8] CYANURIC CHLORIDE DERIVATIVES .3. ALKOXY-S-TRIAZINES [J].

DUDLEY, JR ;

THURSTON, JT ;

SCHAEFER, FC ;

HOLMHANSEN, D ;

HULL, CJ ;

ADAMS, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (07) :2986-2990

[9] New 1,3,5-triazine derivatives as templates for the homogeneous phase synthesis of chemical libraries [J].

Falorni, M ;

Giacomelli, G ;

Mameli, L ;

Porcheddu, A .

TETRAHEDRON LETTERS, 1998, 39 (41) :7607-7610

[10] Organic synthesis on soluble polymer supports: Liquid-phase methodologies [J].

Gravert, DJ ;

Janda, KD .

CHEMICAL REVIEWS, 1997, 97 (02) :489-509

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