Integrin-growth factor interactions,as regulators of oligodendroglial development and function

被引:108
作者
Baron, W
Colognato, H
Ffrench-Constant, C
机构
[1] Univ Groningen, Fac Med Sci, Dept Membrane Cell Biol, NL-9713 AV Groningen, Netherlands
[2] SUNY Stony Brook, Dept Pharmacol, Stony Brook, NY 11794 USA
[3] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
[4] Univ Cambridge, Dept Med Genet, Cambridge, England
[5] Univ Cambridge, Cambridge Ctr Brain Repair, Cambridge, England
关键词
platelet-derived growth factor; neuregulin; extracellular matrix; lipid raft; integrin activation; apoptosis; proliferation; laminin; vitronectin;
D O I
10.1002/glia.20132
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Central nervous system (CNS) development requires mechanisms for the regulation of cell number. Although growth factors are essential determinants of the proliferation and apoptosis that determine final numbers, the long-range nature of signals from diffusible growth factors makes them insufficient for the provision of the precise and localized signals required. Integration of integrin and growth factor receptor signaling in controlling cell behavior has been an important theme of research over the past several years. The focus of this review is on the mechanisms by which integrin-growth factor interactions regulate the development of oligodendrocytes and provide a mechanism for controlling, both in space and in time, oligodendrocyte numbers in the developing CNS. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:467 / 479
页数:13
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