Cortical spreading depression induces an LTP-like effect in rat neocortex in vitro

被引：58

作者：

Footitt, DR

Newberry, NR

机构：

[1] Univ Oxford, Radcliffe Infirm, Dept Clin Pharmacol, Oxford OX2 6HE, England

[2] Univ Oxford, Radcliffe Infirm, SmithKline Beecham Ctr Appl Neuropsychobiol, Oxford OX2 6HE, England

来源：

BRAIN RESEARCH | 1998年 / 781卷 / 1-2期

关键词：

cortical-spreading depression; long-term potentiation; NMDA; AMPA;

D O I：

10.1016/S0006-8993(97)01359-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have developed an in vitro model of spreading depression (SD) in rat neocortex. KCI application induced a propagating wave of SD associated with a change of optical lucency and an extracellular negative wave. Both of these were abolished by aminophosphonovaleric acid (100 mu M), indicating SD's mediation by NMDA receptors. SD abolished synaptically-mediated field potentials in layer II and this depression was followed by a previously undescribed, sustained LTP-Like enhancement of transmission. (C) 1998 Elsevier Science B.V.

引用

页码：339 / 342

页数：4

共 17 条

[1]

Bear M F, 1993, Curr Opin Neurobiol, V3, P197, DOI 10.1016/0959-4388(93)90210-P

[2] POTASSIUM-INDUCED LONG-TERM POTENTIATION IN AREA CA1 OF THE HIPPOCAMPUS INVOLVES PHOSPHOLIPASE ACTIVATION [J].