Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity

被引：64

作者：

Hung, Tran Manh ^{[3
]}

Cao Van Thu ^{[4
]}

Nguyen Tien Dat ^{[5
]}

Ryoo, Sung-Woo ^{[6
]}

Lee, Jeong Hyung ^{[6
]}

Kim, Jin Cheol ^{[7
]}

Na, Minkyun ^{[8
]}

Jung, Hyun-Ju ^{[2
]}

Bae, KiHwan ^{[1
]}

Min, Byung Sun ^{[3
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Wonkwang Univ, Dept Oriental Pharm, Jeonbuk 570749, South Korea

[3] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea

[4] Hanoi Univ Pharm, Hanoi, Vietnam

[5] Vietnamese Acad Sci & Technol, Inst Nat Prod Chem, Hanoi, Vietnam

[6] Kangwon Natl Univ, Coll Nat Sci, Chunchon 200701, South Korea

[7] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[8] Yeungnam Univ, Coll Pharm, Gyeongbuk 712749, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 08期

关键词：

Ophiopogon japonicus; Liliaceae; Homoisoflavonoids; Anti-inflammatory; CONSTITUENTS; EOTAXIN; TUBER; EOSINOPHIL; GLYCOSIDES; CELLS; RECRUITMENT; EXPRESSION; EXTRACT;

D O I：

10.1016/j.bmcl.2010.03.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new homoiso. avonoids (1-3) were isolated from the roots of Ophiopogon japonicus (Liliaceae). The structures of new metabolites were determined on the basis of spectroscopic analyses including 2D NMR. The anti-inflammatory activities of new compounds (1-3) were investigated by their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of IL-4 and TNF-alpha in BEAS-2B cells, which mimics the in vivo conditions in bronchial allergic asthma. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2412 / 2416

页数：5

共 31 条

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