Novel gas-phase ion-molecule aromatic nucleophilic substitution in β-carbolines

被引：11

作者：

Lopes, NP

Fonseca, T

Wilkins, JPG

Staunton, J

Gates, PJ

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

[3] Unilever Safety & Environm Assurance Ctr, Sharnbrook MK44 1LQ, Beds, England

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 01期

关键词：

D O I：

10.1039/b210117c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a novel gas-phase ion-molecule aromatic-nucleophilic substitution reaction between beta-carbolines and water vapour, that accounts for the observation of ions with higher masses than the precursor ion in the MS/MS spectra.

引用

页码：72 / 73

页数：2

共 9 条

[1] EXPERIMENTAL-STUDY ON THE MECHANISM OF GAS-PHASE AROMATIC NITRATION BY PROTONATED METHYL NITRATE [J].

ASCHI, M ;

ATTINA, M ;

CACACE, F ;

RICCI, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (21) :9535-9542

[2] Intrinsic gas-phase electrophilic reactivity of cyclic N-alkyl- and N-acyliminium ions [J].

D'Oca, MGM ;

Moraes, LAB ;

Pilli, RA ;

Eberlin, MN .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (11) :3854-3864

[3] NUCLEAR MAGNETIC RESONANCE SPECTRA OF INTERMEDIATES FORMED BY ACTION OF NUCLEOPHILES ON PYRIDINE AND PYRIDINIUM IONS [J].

FOSTER, R ;

FYFE, CA .

TETRAHEDRON, 1969, 25 (07) :1489-&

[4] Liquid chromatography electrospray mass spectrometry with in-source fragmentation for the identification and quantification of fourteen mutagenic amines in beef extracts [J].

Pais, P ;

Moyano, E ;

Puignou, L ;

Galceran, MT .

JOURNAL OF CHROMATOGRAPHY A, 1997, 775 (1-2) :125-136

[5] Formation of mutagenic/carcinogenic heterocyclic amines in dry-heated model systems, meats, and meat drippings [J].

Pais, P ;

Salmon, CP ;

Knize, MG ;

Felton, JS .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, 47 (03) :1098-1108

[6] NAPHTHYRIDINE CHEMISTRY .9. BROMINATION AND AMINATION OF 1,X-NAPHTHYRIDINES [J].

PAUDLER, WW ;

KRESS, TJ .

JOURNAL OF ORGANIC CHEMISTRY, 1968, 33 (04) :1384-&

[7] High performance liquid chromatography electrospray tandem mass spectrometry (HPLC-ESI-MS-MS) for the analysis of heterocyclic aromatic amines (HAA) [J].

Richling, E ;

Herderich, M ;

Schreier, P .

CHROMATOGRAPHIA, 1996, 42 (1-2) :7-11

[8] Determination of heterocyclic aromatic amines (HAA) in commercially available meat products and fish by high performance liquid chromatography -: Electrospray tandem mass spectrometry (HPLC-ESI-MS-MS) [J].

Richling, E ;

Häring, D ;

Herderich, M ;

Schreier, P .

CHROMATOGRAPHIA, 1998, 48 (3-4) :258-262

[9] THE SYNTHESIS OF DERIVATIVES OF BETA-CARBOLINE .3. THE NITRATION OF HARMAN [J].

SNYDER, HR ;

PARMERTER, SM ;

KATZ, L .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1948, 70 (01) :222-225

← 1 →