Quantitative ultrasound: An indicator of osteoporosis in perimenopausal women

被引:18
作者
Nairus, J [1 ]
Ahmadi, S [1 ]
Baker, S [1 ]
Baran, D [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Orthoped & Phys Rehabil, Worcester, MA USA
关键词
osteoporosis; diagnosis; ultrasound; dual X-ray absorptiometry; perimenopausal;
D O I
10.1385/JCD:3:2:141
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The key to effective treatment of osteoporosis is early detection. To assess the utility of quantitative ultrasound (QUS) at the calcaneus in perimenopausal women, broadband ultrasound attenuation (BUA); speed of sound (SOS); quantitative ultrasound index (QUI), an algorithm of BUA and SOS; and bone mineral density by dual X-ray absorptiometry (DXA) of the posteroanteiror spine, femoral neck, and total hip were measured in 420 women (ages 45-55 yr). Thirty (7.1%) of the women were found to be osteoporotic by DXA. All QUS measurements were predictors of osteoporosis. QUS values did not differ between postmenopausal women on estrogen replacement therapy (ERT) and those not on ERT. There were no differences among BUA, SOS, and QUI in the area under the receiver operating characteristic curves for predicting osteoporotic vs nonosteoporotic cases. At a QUI of 89, ultrasound had an 80% sensitivity for the diagnosis of osteoporosis, but only a 74% specificity. Tho high false-positive rate (26%) limits the utility of QUS as the sole diagnostic technique on which to base therapeutic decisions. Nevertheless, low QUS measurements may provide a means for targeting those women who would benefit most from more extensive evaluation (e.g., DXA).
引用
收藏
页码:141 / 147
页数:7
相关论文
共 30 条
[1]   ULTRASOUND ATTENUATION OF THE CALCANEUS - A SENSITIVE AND SPECIFIC DISCRIMINATOR OF OSTEOPENIA IN POSTMENOPAUSAL WOMEN [J].
AGREN, M ;
KARELLAS, A ;
LEAHEY, D ;
MARKS, S ;
BARAN, D .
CALCIFIED TISSUE INTERNATIONAL, 1991, 48 (04) :240-244
[2]  
Baran D T, 1991, Osteoporos Int, V1, P110, DOI 10.1007/BF01880452
[3]   ULTRASOUND ATTENUATION OF THE OS CALCIS IN WOMEN WITH OSTEOPOROSIS AND HIP-FRACTURES [J].
BARAN, DT ;
KELLY, AM ;
KARELLAS, A ;
GIONET, M ;
PRICE, M ;
LEAHEY, D ;
STEUTERMAN, S ;
MCSHERRY, B ;
ROCHE, J .
CALCIFIED TISSUE INTERNATIONAL, 1988, 43 (03) :138-142
[4]   Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women - A prospective study [J].
Bauer, DC ;
Gluer, CC ;
Cauley, JA ;
Vogt, TM ;
Ensrud, KE ;
Genant, HK ;
Black, DM .
ARCHIVES OF INTERNAL MEDICINE, 1997, 157 (06) :629-634
[5]   Ultrasound velocity and attenuation at different skeletal sites compared with bone mineral density measured using dual energy X-ray absorptiometry [J].
Cunningham, JL ;
Fordham, JN ;
Hewitt, TA ;
Speed, CA .
BRITISH JOURNAL OF RADIOLOGY, 1996, 69 (817) :25-32
[6]   Effect of bovine bone constituents on broadband ultrasound attenuation measurements [J].
Duquette, J ;
Honeyman, T ;
Hoffman, A ;
Ahmadi, S ;
Baran, D .
BONE, 1997, 21 (03) :289-294
[7]   Bone mineral and body composition measurements: Cross-calibration of pencil-beam and fan-beam dual-energy X-ray absorptiometers [J].
Ellis, KJ ;
Shypailo, RJ .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (10) :1613-1618
[8]   Discordance in patient classification using T-scores [J].
Faulkner, KG ;
von Stetten, E ;
Miller, P .
JOURNAL OF CLINICAL DENSITOMETRY, 1999, 2 (03) :343-350
[9]   Quantitative ultrasound techniques for the assessment of osteoporosis: Expert agreement on current status [J].
Gluer, CC .
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (08) :1280-1288
[10]   Comparisons of noninvasive bone mineral measurements in assessing age-related loss, fracture discrimination, and diagnostic classification [J].
Grampp, S ;
Genant, HK ;
Mathur, A ;
Lang, P ;
Jergas, M ;
Takada, M ;
Gluer, CC ;
Lu, Y ;
Chavez, M .
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (05) :697-711