Effects of MK-801 on D1 dopamine receptor-mediated immediate early gene expression in the dopamine-depleted striatum

被引：7

作者：

Ganguly, A ^{[1
]}

Keefe, KA ^{[1
]}

机构：

[1] Univ Utah, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA

来源：

BRAIN RESEARCH | 2000年 / 871卷 / 01期

关键词：

NMDA; basal ganglia; zif268; c-fos; Parkinson; glutamate;

D O I：

10.1016/S0006-8993(00)02435-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous work indicates that intrastriatal administration of MK-801 does not completely block D1 agonist-induced gene expression in dopamine-depleted rats. The present study examined the effects of systemic MK-801 on such gene expression. A low dose of MK-801 did not affect induction of c-fos or zif268. A high dose completely blocked induction of c-fos, but only slightly suppressed zif268. The data suggest that NMDA receptor activity may not always be necessary for D1-induced gene expression. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：156 / 159

页数：4

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