A facile synthsis of 1,1-disubstituted 1,2,3,4-tetrahydro-β-carbolines via trifluoroacetic acid catalyzed Pictet-Spengler reaction using titanium(IV) isopropoxide as an imination reagent

被引：18

作者：

Horiguchi, Y ^{[1
]}

Nakamura, M ^{[1
]}

Kida, A ^{[1
]}

Kodama, H ^{[1
]}

Saitoh, T ^{[1
]}

Sano, T ^{[1
]}

机构：

[1] Showa Pharmaceut Univ, Machida, Tokyo 1948543, Japan

来源：

HETEROCYCLES | 2003年 / 59卷 / 02期

关键词：

D O I：

10.3987/COM-02-S79

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of 1,1-disubstitued 1,2,3,4-tetrahydro-beta-carbolines (13) was achieved in a highly effective manner via the trifluoroacetic acid catalyzed Pictet-Spengler reaction of the keto imines (9) prepared from tryptamine (8) with acyclic and cyclic ketones using titanium(IV) isopropoxide as the imination reagent under one pot procedure. This reaction provides a convenient and general method for preparing various 1,2,3,4-tetrahydro-beta-carbolines derivatives.

引用

页码：691 / 705

页数：15

共 8 条

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