Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active Epstein-Barr virus infection

被引：26

作者：

Fujii, N

Takenaka, K

Hiraki, A

Maeda, Y

Ikeda, K

Shinagawa, K

Ashiba, A

Munemasa, M

Sunami, K

Hiramatsu, Y

Ishimaru, F

Niiya, K

Yoshino, T

Harada, M

机构：

[1] Okayama Univ, Sch Med, Dept Internal Med 2, Okayama 7008558, Japan

[2] Okayama Univ, Sch Med, Dept Pathol 2, Okayama 7008558, Japan

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 07期

关键词：

chronic active Epstein-Barr virus infection; allogeneic peripheral blood stem cell transplantation; myeloablative conditioning regimen; EBV-specific CTL;

D O I：

10.1038/sj.bmt.1702600

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT), On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.

引用

页码：805 / 808

页数：4

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