In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction

被引：536

作者：

Kraitchman, DL

Heldman, AW

Atalar, E

Amado, LC

Martin, BJ

Pittenger, MF

Hare, JM

Bulte, JWM

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA

[3] Osiris Therapeut Inc, Baltimore, MD USA

[4] Bilkent Univ, Dept Elect & Elect Engn, TR-06533 Ankara, Turkey

来源：

CIRCULATION | 2003年 / 107卷 / 18期

关键词：

magnetic resonance imaging; myocardial infarction; cells; contrast media;

D O I：

10.1161/01.CIR.0000070931.62772.4E

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results-Adult farm pigs (n = 5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16 x 10(7) cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion-MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.

引用

页码：2290 / 2293

页数：4

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