Synthesis of novel chiral Schiff-base ligands and their application in asymmetric nitro aldol (Henry) reaction

被引：58

作者：

Colak, Mehmet ^{[1
]}

Aral, Tarik ^{[1
]}

Hosgoeren, Halil ^{[1
]}

Demirel, Nadir ^{[1
]}

机构：

[1] Univ Dicle, Fac Sci, Dept Chem, TR-21280 Diyarbakir, Turkey

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 09期

关键词：

D O I：

10.1016/j.tetasy.2007.04.025

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral Schiff-bases prepared from chiral amino alcohols catalyze the enantio selective Henry (nitro aldol) reaction between nitromethane and p-nitrobenzaldehyde in the presence of Cu(OTf)(2) and Zn(OTf)(2). Zn(OTf)(2) promoted the reaction yield, while Cu(OTf)(2) promoted the enantiomeric excess. The highest enantioselectivities were observed with ligand 3 (44% ee) and ligand 5 (47% ee). (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1129 / 1133

页数：5

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